Genotype is the genetic makeup of an individual with reference
to a trait or multiple traits. They are the collection of genes passed from
parents to the children.
There are four genotypes in humans - AA, AS, SS and AC.
AC genotype is not so common and popular unlike the other three. SS and AC are
the abnormal genotypes or the sickle cells. The knowledge of genotype is
important when choosing life partners. Intending couples should know both their
own genotype as well as their partner's genotype at the early stage of their
relationship before they are well rooted in love and emotions. Emotions and
time spent in the relationship can cloud people’s judgment or decision to break
up if they are not compatible, thus, giving birth to sickle cell children and
subjecting themselves and their children to pain, torture and agony.
Possible Outcomes of Different Genetic Combination
AA + AA = AA, AA, AA, AA
AA + AS = AA, AS, AA, AS
AA + SS = AS, AS, AS, AS
AA + AC = AA, AA, AA, AC
AS + AS = AA, AS, AS, SS
AS + SS = AS, SS, SS, SS
AS + AC = AA, AC, AS,SS
SS + SS = SS, SS, SS, SS
AC + SS = AS, AS, SS, SS
AC + AC = AA, AC, AC, SS
AA + AS = AA, AS, AA, AS
AA + SS = AS, AS, AS, AS
AA + AC = AA, AA, AA, AC
AS + AS = AA, AS, AS, SS
AS + SS = AS, SS, SS, SS
AS + AC = AA, AC, AS,SS
SS + SS = SS, SS, SS, SS
AC + SS = AS, AS, SS, SS
AC + AC = AA, AC, AC, SS
People with the genotype AA are prone to malaria sickness at
their early ages. Sickle cell arises when there is any blockage in the blood
vessels which inhibits the flow of oxygen. When the red blood cell do not have
the required oxygen, there will be changes in its original shape (disc shape)
to a "Sickle-like" or "crescent-like shape", Thus,
the name "sickle cell". Sickle cell patients experience severe pains
in body parts that lack oxygen flow. Their bone marrows will fail to produce
red blood cells and this result to anemia. To save this crisis, blood is usually
transfused to them.
In terms of compatibility, someone with AA genotype can marry anybody. It is safe for someone with AS to marry someone with AA genotype. The combinations of AS and AS, AS and AC should not be risked. There is probability of having a SS. Although. Two sickle cells should not even have a relationship or get married. Individuals with the AA genotype should help you prevent genetic abnormalities by marrying the AS, AC and SS. By this, we are hopeful to eradicate sickle cells in the world.